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- _4 value "consistent with this proposal, all Lxr target genes encode proteins that have major roles in controlling cholesterol and or fatty acid homeostasis in a number of tissues including the liver, intestine, macrophages and possibly adipose tissue primary bile acids, such as CDCA or CA, bind to Fxr in vitro, this interaction occurs at physiological levels of the bile acids this interaction results in recruitment of coactivators to the liganded Fxr, and that there is a subsequent increase in the transcription of target genes Fxr transcripts are restricted to the liver, kidney, intestine [all involved in cholesterol/bile acid metabolism], colon, and adrenals" provenance.
- _4 wasQuotedFrom 11792716 provenance.