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- _3 value "C. Atherosclerosis The involvement of PDGF in the atherosclerosis process has been confirmed experimentally using balloon catheterization of rat carotid arteries as a model. In the denuded artery, an increased amount of activated PDGF receptors is seen in the vessel wall (3, 345). The intimal thickening that follows this treatment was inhibited by administration of neutralizing PDGF antibodies (120). In addition, a low-molecular-weight PDGF receptor kinase inhibitor, AG-1295, was recently shown to inhibit neointima formation in a porcine restenosis model (25). Moreover, infusion of PDGF-BB into rats after carotid injury (210), or expression of recombinant PDGF-BB in porcine arteries (317), caused increased intimal thickening. The role of PDGF in the atherosclerotic lesions may be to stimulate smooth muscle cells to migrate from the media of the vessel to the intima layer and to proliferate and produce matrix molecules at this site (368)." provenance.
- _3 wasQuotedFrom 10508235 provenance.