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- _3 value "Expression of MuRF1 and MAFbx is stimulated when the nerve innervating a muscle is cut, thus resulting in paralysis and severe atrophy; these genes are also upregulated by simple immobilization of the muscle, or by treatment with a glucocorticoid, which causes muscle cachexia [11]. More recently, a predictive experiment was performed, in which sepsis-induced atrophy was induced to determine whether this distinct model of atrophy might also increase expression of MuRF1 and MAFbx. Both of these genes were upregulated several-fold during sepsis [72], and this upregulation could be blocked by a pharmacologic inhibitor of glucocorticoids [72]." provenance.
- _3 wasQuotedFrom 12928036 provenance.