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- _5 value "After Fc?RI-stimulation, Akt (T308) phosphorylation in PTEN-deficient cells was further increased. Akt is well known to function as a PI3K-dependent prosurvival protein through its regulation of Bcl family members, the Forkhead family of transcription factors, and p53 family members (15). Analysis of events that can initiate apoptosis (mitochondrial membrane potential and DNA compaction) under conditions of growth factor starvation revealed a significant reduction (16 h) in these events in PTEN-deficient cells" provenance.
- _5 wasQuotedFrom 16621980 provenance.