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- _3 value "The hereby generated CO has now been postulated to take over the role of NO under oxidative conditions (Foresti and Motterlini, 1999). Pro-inflammatory mediators, like TNF- and heme, activate the transcription factors NF-B, AP-1, and SP-1 signaling pathways via the formation of ROS, which may result in the transcriptional activation of several genes involved in inflammation, such as ICAM-1, VCAM-1, and selectins (Lavrovsky et al., 1994; Shono et al., 1996). " provenance.
- _3 wasQuotedFrom 12869663 provenance.