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- _6 value "hepatic nuclear factor 3 (HNF3) and nuclear factor 1 (NF1) are necessary for an appropriate expression of the ALAS gene. Insulin overrides the HNF3beta or HNF3beta plus NF1-mediated stimulation of ALAS transcriptional activity. Electrophoretic mobility shift assay and Southwestern blotting indicate that HNF3 binds to the ALAS promoter We propose a model in which insulin exerts its negative effect through the disturbance of HNF3beta binding or transactivation potential" provenance.
- _6 wasQuotedFrom 15123725 provenance.