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- _5 value "overexpression of HIPK2 suppresses LEF1/beta-catenin-mediated transcriptional activation of cyclin D1 expression. Our results indicated that HIPK2 suppressed ?-catenin-mediated activation of cyclin D1 (Fig. 3F). The suppressive effect of HIPK2 did not require phosphorylation on the critical Ser/Thr residues of ?-catenin because HIPK2 suppressed the transcriptional activity of a constitutively active form of ?-catenin (CA-?-catenin) in which amino acids 29?48 were deleted (Fig. 3F). Interestingly, the kinase-inactive form of HIPK2 (HIPK2K221A) showed a similar efficacy in suppressing cyclin D1 expression, suggesting that the kinase activity of HIPK2 was dispensable. " provenance.
- _5 wasQuotedFrom 17666529 provenance.