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- _6 value "Once phosphorylated, Cbl can recruit the SH2-containing adaptor protein CrkII to lipid rafts, along with the GEF C3G. C3G then appears to activate the Rho family GTPase TC10. This small GTP-binding protein is produced in fat and muscle and can be acutely activated by insulin in a CAP-dependent but PdtIns-3-kinase-independent manner. Activation of TC10 is specific for insulin, and disruption of its activation blocks insulin-stimulated glucose transport and Glut4 translocation." provenance.
- _6 wasQuotedFrom 11849969 provenance.