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- _4 value "IGF-1 receptor signaling when blocked with anti IGF-1R alpha neutralizing antibody, and when, either the 2.6 kb or the 0.35 kb VPF/VEGF reporter construct was transfected into AsPC-1 cells. The reporter activity of the 2.6 kb VPF/VEGF promoter showed a 50% decrease, and the 0.35kb VPF/VEGF promoter (mainly Sp1 binding sites) showed a 40% decrease compared with that of the IgG control. These results suggested that in AsPC-1 cells, the IGF-1 receptor signaling promotes VPF/VEGF expression mainly through transcriptional regulation, where the transcription factor Sp1 plays an important role." provenance.
- _4 wasQuotedFrom 14604996 provenance.