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- _3 value "AMPK activation in the ?-cell to inhibit glucose metabolism and ATP production (see above), in stark contrast with the situation in most other cell types, where AMPK activation serves to stimulate glycolytic flux and to spare ATP consumption [193], or possibly to the inhibition of insulin release Moreover, metformin activates AMPK in both MIN6 cells and human islets (I. Leclerc, unpublished work), and leptin acutely inhibits insulin secretion from ?-cell lines and islets" provenance.
- _3 wasQuotedFrom 12839490 provenance.