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- _6 value "studies of MCF-7 breast cancer cells stimulated with heregulin showed increased HIF-1a protein synthesis that was inhibited by treatment with rapamycin a macrolide antibiotic that inhibits mammalian target of rapamycin (mTOR; a kinase that functions downstream of PI3K and AKT). The effect of heregulin was mediated via the 5-untranslated region of HIF-1a mRNA47. The known targets for phosphorylation by mTOR are regulators of protein synthesis (FIG. 1)." provenance.
- _6 wasQuotedFrom 13130303 provenance.