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- _7 value "CAPRI-knockout mouse. Cells from this animal have the predicted hyperactivation of Ras signalling, which is consistent with the loss of an important Ras-GAP. Interestingly, Zhang et al. [40] also noted a decrease in the activation of the small GTPases Rac and Cdc42. This effect appeared not to arise through the hyperactivation of Ras, nor was it a consequence of CAPRI functioning as a Cdc42/Rac GEF, rather the authors show that CAPRI, via its Ras-GAP domain, can bind Rac and Cdc42 directly and act as a scaffold for presenting these GTPases to an unidentified GEF. " provenance.
- _7 wasQuotedFrom 17052212 provenance.