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- _4 value "LDL(-) stimulation led to a modest 3-fold Ppara ligand binding domain activation; in the presence of LPL and LDL(-), PPARa activation increased 30-fold....This LPL treatment may have produced greater amounts of the ligands already present in LDL(?), converted less potent ligands to more potent forms, or both....To identify this PPAR?-activating component in LDL(?), hydrolytic products of LPL-treated LDL(?) were extracted and separated using HPLC-MS. The major lipophylic compounds in LDL(?), either with or without LPL treatment, were HpODE and HODE acids" provenance.
- _4 wasQuotedFrom 12878589 provenance.