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- _2 value "Addition of a sulfonylurea to metformin therapy gives an additive glucose- lowering effect (102, 103,149). Similarly, addition of metformin to sulfonylurea therapy gives an additive response, both with respect to glucose-lowering (101, 103, 149-152) and lipid-lowering (91, 103) effects the elevated fasting plasma glucose level is caused by incomplete suppression of basal hepatic glucose production by sulfonylurea or metformin Figure 1. Pathogenesis of type 2 diabetes mellitus. Sites of action of oral agents are indicated. A negative sign indicates inhibition; a positive sign indicates stimulation." provenance.
- _2 wasQuotedFrom 10454950 provenance.