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- _6 value "Second, our recent study suggests that binding of phospho-GSK-3b to ANT {Official Gene Symbol: Slc25a4} suppresses interaction of ANT with CypD {Official Gene Symbol: Ppid}, a trigger of mPTP opening.51 In isolated rat hearts, reperfusion after sustained ischemia induced translocation of cytosolic GSK-3b to the mitochondria, where it formed a complex with ANT and VDAC. Phosphorlylation of GSK-3b by ischemic preconditioning and erythropoietin (EPO) receptor activation was dependent on protein kinase C (PKC) and phosphatidiylinositol 3-phosphate kinase (PI3K), and phospho-GSK-3b was bound to ANT but not to VDAC at reperfusion (Figure 2A). {Phosphorylation of GSK3b is at what's described in the literature as Serine 9}" provenance.
- _6 wasQuotedFrom 19506320 provenance.