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- _4 value "conducted using human breast cancer cells, BRCA1 protein inhibited ER-a-mediated transcriptional pathways related to cell proliferation. This finding suggests that in addition to maintaining genomic stability during periods of rapid cellular division and multiplication, BRCA1 may also suppress signaling initiated by estrogen-induced activation of ER-a... A loss of BRCA1 function leads to increased proliferation of malignant cells in cell culture (56, 57), and stable transfection of wild-type BRCA1 into these cells inhibits their growth (58). However, activation of BRCA1 seen during puberty and pregnancy does not seem to block proliferation occurring in the breast at these times." provenance.
- _4 wasQuotedFrom 11016617 provenance.