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- _6 value "The results showed that transcriptional activation of the SRE by E2 was due to ERalpha activation of the MAPK pathway...The role of ERalpha expression in mediating increased reporter gene activity was further investigated and shown to be related to enhanced ERK1/2 activation...in cells transfected with pSS and ERalpha or HE11 (DNA binding domain deletion), E2 induced CAT activity; similar results were observed for CHO cells using pSRE (Fig. 3E), suggesting that this kinase-dependent response is not associated with nuclear ERalpha action. " provenance.
- _6 wasQuotedFrom 11145955 provenance.