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- _3 value "natural FXR agonist chenodeoxycholic acid (CDCA) Interestingly, a significant increase of transcript level of the very low density lipoprotein receptor (VLDLR) was observed. Our data, resulting from selective FXR activation, FXR RNA silencing and FXR-deficient mice, clearly demonstrate that BAs up-regulate VLDLR transcript levels via a FXR-dependent mechanism in vitro in human and in vivo in mouse liver cells." provenance.
- _3 wasQuotedFrom 15147890 provenance.