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- _5 value "PDK-1 is a downstream molecule of PI3K, which activates among many others, PKC-z (37). This protein kinase is a member of the atypical PKCs. Unlike conventional or novel PKCs, it does not require diacylglycerol or phorbol esters for its activation and its function is Ca2+ independent (38). To achieve catalytic potential, PKC-z needs to be phosphorylated on threonine 410 (T410) through PDK-1 (37, 39)." provenance.
- _5 wasQuotedFrom 14604996 provenance.