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- _5 value "Following ligand binding to the IL-10R, Jak1 and Tyk2, which are constitutively associated with IL-10R1 and IL-10R2, respectively (3, 14), are phosphorylated on tyrosine The phosphorylated IL-10R/Jak1/Tyk2 complex serves as a docking site for the transcription factors Stat-1 and Stat-3 Jak1, which is required for the biological activity of IL-10 (20), also tyrosine phosphorylates the insulin receptor substrate-1 (IRS-1)" provenance.
- _5 wasQuotedFrom 11591769 provenance.