Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAxZ3khDFk_W0UEKkk_43XdIReb0xT250l45Xkx6w-h3c#_4> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _4 value "We recently identified three powerful RET inhibitors: two pyrazolo-pyrimidines: 4-amino-5-(4-methylphenyl)- 7-(t-butyl)pyrazolo[3,4-d]-pyrimidine (PP1) and 4-amino- 5-(4-chloro-phenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine) (PP2), and an anilino- quinazoline: N (4 bromo 2 fluorophenyl) 6 methoxy 7 (1 methylpiperidin 4 yl) methoxy quinazolin 4 amine (ZD6474) [86 88]. These compounds showed half-maximal RET inhibitory concentrations in the nanomolar range (100 nM). When injected into nude mice, fibroblasts transfected with oncogenic RET lost morphological transformation, proliferative autonomy, anchorage-independent growth and tumorigenicity. In addition to inhibition of RET phosphorylation, PP1 induces RET destruction through proteosomal degradation [89]." provenance.
- _4 wasQuotedFrom 15583857 provenance.