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- _5 value "After binding of ligand, either estrogens or antiestrogens, to the ER, the receptor dimerizes with another receptor-monomer to somehow activate the complex and to facilitate the binding of the receptor dimer to the EREs of target genes... ERalpha and ERbeta can heterodimerize, and ERbeta appears to have different functional properties Other nuclear proteins can interact with the ER dimer to modify the expression of certain genes...Some of these receptor-interacting proteins function as co-activators to amplify transcription activation from the ER, while others function as co-repressors. Molecules that have been identified to act as ER co-activators include SRC-1 and SRC-2, CBP/p300, TIF-2,TRIP-1, and AIB-1 ...AIB(also called SRC-3 or Rac3) is amplififed and/or overexpressed in a large percentage of human breast cancer specimens, suggesting that it may have an important role in breast cancer development N-CoR and SMRT function as co-repressors and bind to the ER either in the absence of estrogen or in the presence of tamoxifen progression" provenance.
- _5 wasQuotedFrom 10068081 provenance.