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- _4 value "Phosphotyrosine phosphatases (PTPases). PTPases are responsible for dephosphorylation of the insulin receptor and its substrates, and hence, turning off the insulin signal. To date, no insulin receptor-specific phosphatase has been identified. Total membrane-bound tyrosine phosphatase activity is increased in skeletal muscle of type 2 diabetic patients (158). Immunodepletion experiments in muscles from these diabetic patients and obese individuals suggest that especially two phosphatases, protein-tyrosine phosphatase 1B (PTP-1B) and leukocyte antigen-related (LAR) phosphatase, are mainly responsible for this increase (159)." provenance.
- _4 wasQuotedFrom 10194465 provenance.