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- _5 value "in mammary epithelium, b4-integrin was found to cooperate with EGF-R in epidermal keratinocytes to enhance proliferation in a Src- but not Rasdependent manner. Signaling-wise this involves mainly the mitogen-activated protein kinase (MAPK) kinase module JNK/c-Jun and contributing activation of signal transducer and activator of transcription 3 (STAT3), whereas the PI3K/Akt kinase survival axis (protein kinase B) was suggested to be activated by b4-integrin and/or RTK alone (see Figure 2" provenance.
- _5 wasQuotedFrom 18268536 provenance.