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- _7 value "Transcriptional activation involves alterations in chromatin structure mediated by ATP-dependent chromatin-remodeling enzymes in conjunction with factors that contain histone acetyltransferase (HAT) activity [17]. Consistent with this concept is the observation that ER recruits BRG1, a mammalian homologue of a component of the SWI/SNF chromatin remodeling complex, to EREs in a cooperative manner with HATs [18]. Further, many ER coactivators possess intrinsic HAT activities, including CBP/p300, p/CAF, and TAFII250 [19-21]. Other coactivators such as the p160 coactivators facilitate ER transcription by serving as platforms to recruit HATs and protein methyltransferases." provenance.
- _7 wasQuotedFrom 14680484 provenance.