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- _3 value "Whole blood from a healthy human donor was exposed at 37 degrees C to 137Cs gamma-radiations (absorbed dose: 1-4 Gy). Fifteen minutes following irradiation the lymphocytes were isolated from the blood (for 2 h at 20 degrees C) and their gene expression was investigated using the DNA-microarrays.Up-regulation of expression was observed in 15 genes: CD69 (CD69 molecule), CDKN1A (cyclin-dependent kinase inhibitor 1A), EGR1 (early growth response 1), EGR4 (early growth response 4), FLJ35725 (chromosome 4 ORF 23), hCG2041177 (hCG - human Celera Genome), hCG1643466.2, IFN-gamma (interferon-gamma), ISG20L (interferon stimulated exonuclease gene 20 kDa - like 1), c-JUN (jun oncogene), MDM2 (mouse double minute 2), MUC5B (mucine), PLK2 (polo-like kinase 2), RND1 (rho-family GTPase 1) and TNFSF9 (tumour necrosis factor superfamily member 9). Down-regulation of expression was found in the remaining nine genes: GRIK3 (glutamate receptor ionotropic kainate 3), hCG1985174, hCG1998530, hCG2038519, OCLN (occludin), RPL10A (ribosomal protein L10a), SERHL2 (serine hydrolase-like 2), SGK3 (serum/glucocorticoid regulated kinase 3) and STARD13 (START domain containing 13)." provenance.
- _3 wasQuotedFrom 18464067 provenance.