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- _5 value "Akt-dependent phosphorylation of Bad on Ser112 and Ser136 allows it to associate with 14-3-3 proteins and thereby suppresses its pro-apoptotic activity. Apoptotic kinases including JNK directly activate the cell death machinery by phosphorylating Bad at Serine 128 (Donovan et al., 2002Go). The phosphorylation of Bad at this residue disrupts the interaction of Bad with 14-3-3 proteins, thus allowing Bad to induce apoptosis (Konishi et al., 2002Go)." provenance.
- _5 wasQuotedFrom 14673001 provenance.