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- _5 value "Recent studies in endothelial cells have shown that TGF-? signals through ALK1, activating the Smad1/5 pathway, and through ALK5, activating the Smad2/3 pathway [6]. These two pathways have in a dose-dependent manner opposing effects on endothelial cell behaviour: ALK1 promotes cell proliferation and migration, whereas ALK5 inhibits both processes." provenance.
- _5 wasQuotedFrom 16594992 provenance.