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- _5 value "Although the evidence implicating Egr-1 in IMPDH type II expression is circumstantial at present, the presence of a protected region (C) corresponding to the Egr-1 binding site in the IMPDH type II promoter and the requirement for increased IMPDH gene expression for T lymphocyte activation do suggest that this site could be of considerable functional importance. It has been observed, for example, that Egr-1 can act as a repressor of Sp1 activity at the coincident binding site in the adenosine deaminase gene promoter" provenance.
- _5 wasQuotedFrom 7896827 provenance.