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- _5 value "Shc and FRS2 mediates recruitment of Grb2-SOS complexes leading to Ras/ERK stimulation, and of Grb2-GAB1/2 complexes leading to stimulation of the phosphatidylinositol-3-kinase (PI3K)/AKT pathway. ShcC and IRS are required to trigger PI3K/AKT activation." provenance.
- _5 wasQuotedFrom 15583857 provenance.