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- _3 value "This modification is necessary for the association of BAD with the 14-3-3 proteins, which prevents BAD translocation to the mitochondria and its interaction with Bcl-XL or Bcl-2 (52, 19), thus allowing the latter proteins to promote cell survival. least as effectively as the wild-type protein, and is more potent than wild-type BAD in inducing cytochrome c release. Phosphorylation of BAD correlates with its ability to interact with 14-3-3 beta, an association necessary for sequestration of BAD in the cytoplasm WT, mutated, and truncated forms of BAD all induced the release of cytochrome c from isolated mitochondria" provenance.
- _3 wasQuotedFrom 11287608 provenance.