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- _6 value "Here we show that mTOR inhibition by hypoxia requires the TSC1/TSC2 tumor suppressor complex and the hypoxia-inducible gene REDD1/RTP801. Disruption of the TSC1/TSC2 complex through loss of TSC1 or TSC2 blocks the effects of hypoxia on mTOR, as measured by changes in the mTOR targets S6K and 4EBP1, and results in abnormal accumulation of Hypoxia-inducible factor (HIF)." provenance.
- _6 wasQuotedFrom 15545625 provenance.