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- _6 value "PKB/ Akt-dependent signaling controls many essential cellular processes such as cellular metabolism, transcription, cell proliferation, migration and survival [37,73,74]. PKB/Akt is believed to promote endothelial cell survival and angiogenesis via the phosphorylation and inactivation of the pro-apoptotic molecules Bad, Bax, caspase 9, and the Forkhead (FRKH) transcription factor [75], the stimulation of nitric oxide (NO) production [76,77], and the inhibition of the stressactivated kinases p38 and JNK [78]." provenance.
- _6 wasQuotedFrom 14984767 provenance.