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Matches in Nanopublications for { ?s ?p ?o <http://bio2rdf.org/drugbank:DB01242_nanopub.RAHUnokAn1cTtk_KjWHbNXZDhkSWBFf7zRsOCGkwwnS3A#assertion>. }

• drugbank:DB01242 type drugbank_vocabulary:Drug assertion.
• drugbank:DB01242 label "Clomipramine [drugbank:DB01242]" assertion.
• drugbank:DB01242 seeAlso DB01242 assertion.
• drugbank:DB01242 seeAlso clomipramine.html assertion.
• drugbank:DB01242 seeAlso ana1020.shtml assertion.
• drugbank:DB01242 seeAlso clomipr.htm assertion.
• drugbank:DB01242 identifier "drugbank:DB01242" assertion.
• drugbank:DB01242 description "Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, clomipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as clomipramine, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H₁ receptors, α₁-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Clomipramine may be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette’s disorder). Unlabeled indications include panic disorder, chronic pain (e.g. central pain, idiopathic pain disorder, tension headache, diabetic peripheral neuropathy, neuropathic pain), cataplexy and associated narcolepsy, autistic disorder, trichotillomania, onchophagia, stuttering, premature ejaculation, and premenstrual syndrome. Clomipramine is rapidly absorbed from the gastrointestinal tract and demethylated in the liver to its primary active metabolite, desmethylclomipramine." assertion.
• drugbank:DB01242 title "Clomipramine" assertion.
• drugbank:DB01242 bio2rdf_vocabulary:identifier "DB01242" assertion.
• drugbank:DB01242 bio2rdf_vocabulary:namespace "drugbank" assertion.
• drugbank:DB01242 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB01242" assertion.
• drugbank:DB01242 bio2rdf_vocabulary:x-identifiers.org DB01242 assertion.
• drugbank:DB01242 drugbank_vocabulary:drugbank-id "APRD00253" assertion.
• drugbank:DB01242 drugbank_vocabulary:drugbank-id "DB01242" assertion.
• drugbank:DB01242 drugbank_vocabulary:drugbank-id "DB07600" assertion.
• drugbank:DB01242 drugbank_vocabulary:x-cas cas:303-49-1 assertion.
• drugbank:DB01242 drugbank_vocabulary:x-pdb pdb:CXX assertion.
• drugbank:DB01242 drugbank_vocabulary:x-ahfs ahfs:28:16.04.28 assertion.
• drugbank:DB01242 drugbank_vocabulary:x-atc atc:N06AA04 assertion.
• drugbank:DB01242 drugbank_vocabulary:x-chebi chebi:47780 assertion.
• drugbank:DB01242 drugbank_vocabulary:x-dpd dpd:2244818 assertion.
• drugbank:DB01242 drugbank_vocabulary:x-kegg kegg:C06918 assertion.
• drugbank:DB01242 drugbank_vocabulary:x-kegg kegg:D00811 assertion.
• drugbank:DB01242 drugbank_vocabulary:x-pharmgkb pharmgkb:PA449048 assertion.
• drugbank:DB01242 drugbank_vocabulary:x-wikipedia wikipedia:Clomipramine assertion.
• drugbank:DB01242 drugbank_vocabulary:x-bindingdb bindingdb:50021927 assertion.
• drugbank:DB01242 drugbank_vocabulary:x-ndc ndc:0781-2027-31 assertion.
• drugbank:DB01242 drugbank_vocabulary:x-gtp gtp:2398 assertion.
• drugbank:DB01242 drugbank_vocabulary:x-iuphar iuphar:2398 assertion.