Matches in Nanopublications for { <http://bio2rdf.org/drugbank:DB01242> ?p ?o ?g. }
- drugbank:DB01242 type drugbank_vocabulary:Drug assertion.
- drugbank:DB01242 label "Clomipramine [drugbank:DB01242]" assertion.
- drugbank:DB01242 seeAlso DB01242 assertion.
- drugbank:DB01242 seeAlso clomipramine.html assertion.
- drugbank:DB01242 seeAlso ana1020.shtml assertion.
- drugbank:DB01242 seeAlso clomipr.htm assertion.
- drugbank:DB01242 identifier "drugbank:DB01242" assertion.
- drugbank:DB01242 description "Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or arousal, but may cause sedation. In depressed individuals, clomipramine exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as clomipramine, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline and desipramine. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Clomipramine may be used to treat obsessive-compulsive disorder and disorders with an obsessive-compulsive component (e.g. depression, schizophrenia, Tourette’s disorder). Unlabeled indications include panic disorder, chronic pain (e.g. central pain, idiopathic pain disorder, tension headache, diabetic peripheral neuropathy, neuropathic pain), cataplexy and associated narcolepsy, autistic disorder, trichotillomania, onchophagia, stuttering, premature ejaculation, and premenstrual syndrome. Clomipramine is rapidly absorbed from the gastrointestinal tract and demethylated in the liver to its primary active metabolite, desmethylclomipramine." assertion.
- drugbank:DB01242 title "Clomipramine" assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00488_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB01365 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00241_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01171_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00726_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00388_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00852_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB01363 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00615_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00368_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00582_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB01624 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00193_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00575_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00501_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00668_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00237_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00176_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00706_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00285_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00752_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01208_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB06700 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01072_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00472_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00539_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01001_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01064_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB01341 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB02546 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01105_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00427_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01170_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00315_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00864_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB01366 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB01364 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00246_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00816_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00209_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00382_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB01346 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB08919 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01045_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00662_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00988_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00604_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB01367 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00841_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB01291 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00365_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00723_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00908_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00871_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB01623 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB01288 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00503_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00656_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00342_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00857_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00780_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00208_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00675_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB08920 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB01247 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00397_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00730_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB01242_DB06697 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00843_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00610_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00674_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:ddi-interactor-in drugbank_resource:DB00989_DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:food-interaction drugbank_resource:4f8e7d7b7a03f80525934a074d9e985b assertion.
- drugbank:DB01242 bio2rdf_vocabulary:identifier "DB01242" assertion.
- drugbank:DB01242 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB01242 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB01242" assertion.
- drugbank:DB01242 bio2rdf_vocabulary:x-identifiers.org DB01242 assertion.
- drugbank:DB01242 drugbank_vocabulary:drugbank-id "APRD00253" assertion.
- drugbank:DB01242 drugbank_vocabulary:drugbank-id "DB01242" assertion.
- drugbank:DB01242 drugbank_vocabulary:drugbank-id "DB07600" assertion.
- drugbank:DB01242 drugbank_vocabulary:x-cas cas:303-49-1 assertion.
- drugbank:DB01242 drugbank_vocabulary:x-pdb pdb:CXX assertion.
- drugbank:DB01242 drugbank_vocabulary:x-ahfs ahfs:28:16.04.28 assertion.
- drugbank:DB01242 drugbank_vocabulary:x-atc atc:N06AA04 assertion.
- drugbank:DB01242 drugbank_vocabulary:x-chebi chebi:47780 assertion.
- drugbank:DB01242 drugbank_vocabulary:x-dpd dpd:2244818 assertion.
- drugbank:DB01242 drugbank_vocabulary:x-kegg kegg:C06918 assertion.
- drugbank:DB01242 drugbank_vocabulary:x-kegg kegg:D00811 assertion.
- drugbank:DB01242 drugbank_vocabulary:x-pharmgkb pharmgkb:PA449048 assertion.
- drugbank:DB01242 drugbank_vocabulary:x-wikipedia wikipedia:Clomipramine assertion.
- drugbank:DB01242 drugbank_vocabulary:x-bindingdb bindingdb:50021927 assertion.