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- _5 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _4 value "As shown in Fig. 6, the canonical MAP kinase pathway contains a cascade of kinase activation. Typically, an external signal or event eventually activates a MAP3K that then activates a MAP2K, which finally activates the MAPK (ERK, p38, JNK). In the p38MAPK branch, the directly relevant upstream kinases are MKK3 and MKK6, which appear to have redundant functions. Ask1, MEKK3 and Tak1 are amongst several possible MAP3K candidates for the p38MAPK branch, although these MAP3K often activate multiple MAPK pathways (reviewed in Kyriakis and Avruch, 2001). The focus of this section will be on the p38MAPK and MKK3/MKK6. Two early studies suggested that p38 MAPK activity leads to the repression of the Cyclin D1 promoter and to inhibition of G1 progression (Lavoie et al., 1996 and Molnar et al., 1997)." provenance.
- _4 wasQuotedFrom 15225871 provenance.
- assertion hadPrimarySource 15225871 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom _4 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- large_corpus.bel authoredBy _5 provenance.
- large_corpus.bel version "20131211" provenance.