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- _3 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _2 value "The mobilization of Ca2? from intracellular stores leading to a rapid and transient increase in [Ca2? ]i is one of the earliest events stimulated by agonist binding to CCKB/gastrin receptor in many cell types (Rozengurt and Walsh, 2001).The activation of this receptor induces Gaq-mediated stimulation of phospholipase C (PLC) which catalyses the hydrolysis of phosphatidyl inositol 4,5-bisphosphate (PIP2) in the plasma membrane to produce two second messengers: inositol 1,4,5-trisphosphate (ins(1,4,5)P3) and 1,2,-diacylglycerol (DAG) (Exton, 1996). Ins(1,4,5)P3 binds to its intracellular receptor, a ligand-gated Ca2? channel located in the endoplasmic reticulum, and triggers the release of Ca2? from internal stores (Exton, 1996; Mikoshiba, 1997; Rozengurt, 1998)." provenance.
- _2 wasQuotedFrom 11748587 provenance.
- assertion hadPrimarySource 11748587 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom _2 provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- large_corpus.bel authoredBy _3 provenance.
- large_corpus.bel version "20131211" provenance.