Matches in Nanopublications for { <http://www.tkuhn.ch/bel2nanopub/RAbDAo0LYBALUawO4L6pOrtBls-dY_zglFFP7fdDhOnkY#_2> ?p ?o ?g. }
Showing items 1 to 2 of
2
with 100 items per page.
- _2 value "The mobilization of Ca2? from intracellular stores leading to a rapid and transient increase in [Ca2? ]i is one of the earliest events stimulated by agonist binding to CCKB/gastrin receptor in many cell types (Rozengurt and Walsh, 2001).The activation of this receptor induces Gaq-mediated stimulation of phospholipase C (PLC) which catalyses the hydrolysis of phosphatidyl inositol 4,5-bisphosphate (PIP2) in the plasma membrane to produce two second messengers: inositol 1,4,5-trisphosphate (ins(1,4,5)P3) and 1,2,-diacylglycerol (DAG) (Exton, 1996). Ins(1,4,5)P3 binds to its intracellular receptor, a ligand-gated Ca2? channel located in the endoplasmic reticulum, and triggers the release of Ca2? from internal stores (Exton, 1996; Mikoshiba, 1997; Rozengurt, 1998)." provenance.
- _2 wasQuotedFrom 11748587 provenance.