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- _4 label "Selventa" provenance.
- large_corpus.bel rights "Copyright (c) 2011-2012, Selventa. All rights reserved." provenance.
- _3 value "The forkhead box class O (FOXO) transcription factors family members, FOXO1a and FOXO3a, are phosphorylated in an AKT-dependent manner in SCF-stimulated BMMCs [76]. FOXO3a phosphorylation leads to its proteosomal degradation following ubiquitination thereby blocking its transcriptional control of the pro-apopototic factor, Bim. SCF also induces the AKT- and MAPK-dependent phosphorylation of Bim in mouse bone marrow-derived mast cells and it has been proposed that this also leads to its proteosomal degradation [76]. Thus these observations would account for the ablity of PI3K-AKT driven pathways to promote mast cell survival." provenance.
- _3 wasQuotedFrom 18775670 provenance.
- assertion hadPrimarySource 18775670 provenance.
- large_corpus.bel title "BEL Framework Large Corpus Document" provenance.
- large_corpus.bel description "Approximately 61,000 statements." provenance.
- assertion wasDerivedFrom large_corpus.bel provenance.
- assertion wasDerivedFrom _3 provenance.
- large_corpus.bel authoredBy _4 provenance.
- large_corpus.bel version "20131211" provenance.