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- _3 value "The forkhead box class O (FOXO) transcription factors family members, FOXO1a and FOXO3a, are phosphorylated in an AKT-dependent manner in SCF-stimulated BMMCs [76]. FOXO3a phosphorylation leads to its proteosomal degradation following ubiquitination thereby blocking its transcriptional control of the pro-apopototic factor, Bim. SCF also induces the AKT- and MAPK-dependent phosphorylation of Bim in mouse bone marrow-derived mast cells and it has been proposed that this also leads to its proteosomal degradation [76]. Thus these observations would account for the ablity of PI3K-AKT driven pathways to promote mast cell survival." provenance.
- _3 wasQuotedFrom 18775670 provenance.