Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _5 value "PDK can in turn phosphorylate and activate Akt [also known as protein kinase B (PKB)] as well as the atypical protein kinase C isoforms PKCz and PKCl" provenance.
- _5 value "insulin receptor is a tyrosine kinase that catalyzes the phosphorylation of several intracellular substrates, including the insulin receptor substrate (IRS) proteins, GAB-1, Shc, APS, p60(DOK), SIRPS, and c-Cbl" provenance.
- _3 value "these data demonstrate the need for PtdIns 3-kinase in insulin signaling" provenance.
- _5 value "Table 1 - Gene regulated by overexpressing HOXD3 in A549 lung cancer cell lines by more than 1.6 fold." provenance.
- _5 value "Table 1 - Gene regulated by overexpressing HOXD3 in A549 lung cancer cell lines by more than 1.6 fold." provenance.
- _5 value "Table 1 - Gene regulated by overexpressing HOXD3 in A549 lung cancer cell lines by more than 1.6 fold." provenance.
- _5 value "Table 1 - Gene regulated by overexpressing HOXD3 in A549 lung cancer cell lines by more than 1.6 fold." provenance.
- _5 value "Table 1 - Gene regulated by overexpressing HOXD3 in A549 lung cancer cell lines by more than 1.6 fold." provenance.
- _5 value "Table 1 - Gene regulated by overexpressing HOXD3 in A549 lung cancer cell lines by more than 1.6 fold." provenance.
- _5 value "Table 1 - Gene regulated by overexpressing HOXD3 in A549 lung cancer cell lines by more than 1.6 fold." provenance.
- _5 value "Table 1 - Gene regulated by overexpressing HOXD3 in A549 lung cancer cell lines by more than 1.6 fold." provenance.
- _5 value "Table 1 - Gene regulated by overexpressing HOXD3 in A549 lung cancer cell lines by more than 1.6 fold." provenance.
- _5 value "Table 1 - Gene regulated by overexpressing HOXD3 in A549 lung cancer cell lines by more than 1.6 fold." provenance.
- _5 value "Table 1 - Gene regulated by overexpressing HOXD3 in A549 lung cancer cell lines by more than 1.6 fold." provenance.
- _4 value "The cells treated HGF showed significant increased and phosphorylation at tyrosine of Met, a HGF receptor. The level of tyrosine phosphorylation of Met in SP1 cells was dramatically reduced in cells within 60 min after detachment and is restored within 15 min of incubation with HGF. Met was constitutively phosphorylated at tyrosine residues in SP1 cells adhering to, and spreading on, FN substratum and shows a further increase after addition of HGF. Tyrosine phosphorylation of Met in carcinoma cells was augmented by cell adhesion and spreading on fibronectin substratum. In contrast, detached serum-starved cells exhibited reduced tyrosine phosphorylation of Met and undergo apoptotic cell death within 18 to 24 h." provenance.
- _3 value "Modified assertion" provenance.
- _4 value "In macrophages, PPARs inhibit inflammatory cytokine-induced activation [17], promote apoptosis [13] and control lipid homeostasis through their effects on the expression of several key genes including SR-A, CD36, SR-BI and ABCA1." provenance.
- _3 value "Since PPARs have been shown to activate LPL gene expression at the transcriptional level via a PPRE in its promoter [21], the influence of PPAR agonists on LPL gene expression in human macrophages was evaluated The average relative increase of LPL mRNA normalized to control 36B4 mRNA levels, as determined by two independent experiments on different macrophage preparations, was approximately 3-, 4-, 3-, and 3.4-fold for rosiglitazone (50 nM), Wy14643 (20 M), GW2331 (200 nM) and PG-J2 (1 M), respectively" provenance.
- _4 value "our results on the effects of PPAR on reduction of macrophage LPL secretion and activity appear in contrast with previous observations published while this work was in progress [46], demonstrating an increase of extra- and intracellular LPL mass and activity in murine J774 macrophages after treatment with natural fatty acid-derived PPAR activators, such as palmitic acid, stearic acid and linoleic acid" provenance.
- _3 value "The CD163 expression is induced by interleukin-6, interleukin-10 and glucocorticoids." provenance.
- _4 value "In CD14(high) HGF, IFN-gamma markedly up-regulated CD14 and MyD88 but not TLR4 protein and MD-2 mRNA expression, while in CD14(low) HGF, IFN-gamma slightly increased MyD88 and scarcely affected CD14, TLR4 protein, and MD-2 mRNA levels." provenance.
- _5 value "he DNA binding activities of c-Fos, FosB/Delta FosB, Fra-1, Fra-2, and JunB were up-regulated whereas JunD activity was decreased." provenance.
- _5 value "he DNA binding activities of c-Fos, FosB/Delta FosB, Fra-1, Fra-2, and JunB were up-regulated whereas JunD activity was decreased." provenance.
- _5 value "he DNA binding activities of c-Fos, FosB/Delta FosB, Fra-1, Fra-2, and JunB were up-regulated whereas JunD activity was decreased." provenance.
- _5 value "he DNA binding activities of c-Fos, FosB/Delta FosB, Fra-1, Fra-2, and JunB were up-regulated whereas JunD activity was decreased." provenance.
- _7 value "The inhibition appears to be specific for polymerase II as disruption of lamin organization does not detectably inhibit RNA polymerases I and III. Furthermore, immunofluorescence observations indicate that this selective inhibition of polymerase II-dependent transcription involves the TATA binding protein, a component of the basal transcription factor TFIID." provenance.
- _4 value "Modified assertion" provenance.
- _4 value "IGF-1 treatment increased the phosphorylation of eukaryotic initiation factor (eIF)-4E-binding protein 1 (4E-BP1), exclusively at Thr-36 and Thr-45 residues, and eIF-4G phosphorylation at Ser-1108" provenance.
- _4 value "IGF-1 treatment increased the phosphorylation of eukaryotic initiation factor (eIF)-4E-binding protein 1 (4E-BP1), exclusively at Thr-36 and Thr-45 residues, and eIF-4G phosphorylation at Ser-1108" provenance.
- _4 value "In contrast, a significant eIF-4E dephosphorylation was found." provenance.
- _3 value "Connective tissue growth factor (CTGF) was among those genes that showed the most striking up-regulation by mechanical stress." provenance.
- _5 value "dematin blocks transcriptional activation of Jun by Ras-GRF2 and activates ERK1 via a Ras-GRF2 independent pathway" provenance.
- _6 value "In addition to enhanced VAV1 phosphorylation upon anti-CD3E or anti-CD3E/anti-CD28 s timulation, Chiang et al. (2000) detected much higher VAV1/GEF {601855} activity in CBLB-deficient cells than in wildtype cells." provenance.
- _4 value "This corresponded with an adhesion-dependent increase in Tyr-phosphatase activity of PTEN." provenance.
- _3 value "Modified assertion" provenance.
- _6 value "Truncation of signal transducer and activator of transcription (STAT) 5 at the carboxy-terminal domain, either by genetic engineering or by proteolytic cleavage, results in generation of dominant-negative forms. Nuclear element is not necessary for calpain-mediated STAT5 cleavage, since this process occurs in platelets. We also found that STAT3 is a substrate for calpain in vivo and in vitro, indicating that calpain-mediated cleavage is a common feature of STAT3 and STAT5." provenance.
- _6 value "we and others identified numerous substrates for calpain, including p60src, PTP1B, and focal adhesion kinase.13-17" provenance.
- _7 value "we and others identified numerous substrates for calpain, including p60src, PTP1B, and focal adhesion kinase.13-17" provenance.
- _7 value "we and others identified numerous substrates for calpain, including p60src, PTP1B, and focal adhesion kinase.13-17" provenance.
- _3 value "The P1 and P2 proteins interact with elongation factors EF1 and EF2, and the level of their phosphorylation is one of the regulatory mechanisms for the overall rate of protein elongation. Thus, reduced expression of P1 and P2 proteins can affect the rate of protein translation, thereby decreasing proliferation rate of cells." provenance.
- _2 value "Conversely, antidiabetic glitazones and hypolipidemic fibrate drugs, known as PPARgamma and PPARalpha ligands, respectively, reduce the process of atherosclerotic lesion formation" provenance.
- _3 value "The natural PPAR{gamma} ligand 15d-PGJ2 as well as three different synthetic PPAR{gamma} ligands (BRL49653, troglitazone, and ciglitazone) effectively repressed this induction of MHC-II by IFN-{gamma} (Figure 2a) in a dose-dependent manner (Figure 2b), " provenance.
- _4 value "The natural PPAR{gamma} ligand 15d-PGJ2 as well as three different synthetic PPAR{gamma} ligands (BRL49653, troglitazone, and ciglitazone) effectively repressed this induction of MHC-II by IFN-{gamma} (Figure 2a) in a dose-dependent manner (Figure 2b), " provenance.
- _6 value "Modified assertion" provenance.
- _5 value "Modified assertion" provenance.
- _3 value "Transient reporter assays showed that both inhibitors repress muscle creatine kinase (MCK) and myogenin gene transcription." provenance.
- _3 value "Transient reporter assays showed that both inhibitors repress muscle creatine kinase (MCK) and myogenin gene transcription." provenance.
- _4 value "Transient reporter assays showed that both inhibitors repress muscle creatine kinase (MCK) and myogenin gene transcription." provenance.
- _3 value "Additional hormones/agents were tested, including steroids, leptin, an adenosine analog, and norepinephrine. Only the latter compound increased VEGF production, and this effect was mediated by adenylate cyclase. # Ariadne: Norepinephrine at pharmacological concentrations (1... 10 .. M ) stimulated VEGF. [Regulation]" provenance.
- _4 value "Multiple genes are induced following FGF stimulation in chondrocytes, which has been shown by DNA array screening and confirmed for some by immunoblotting. These genes include regulators of cell differentiation and proliferation such as c-jun, JunD, cyclin-D1, NFkappaB1 and of plasma-membrane microdomain morphology, such as ezrin." provenance.
- _4 value "Multiple genes are induced following FGF stimulation in chondrocytes, which has been shown by DNA array screening and confirmed for some by immunoblotting. These genes include regulators of cell differentiation and proliferation such as c-jun, JunD, cyclin-D1, NFkappaB1 and of plasma-membrane microdomain morphology, such as ezrin." provenance.
- _4 value "Multiple genes are induced following FGF stimulation in chondrocytes, which has been shown by DNA array screening and confirmed for some by immunoblotting. These genes include regulators of cell differentiation and proliferation such as c-jun, JunD, cyclin-D1, NFkappaB1 and of plasma-membrane microdomain morphology, such as ezrin." provenance.
- _4 value "Cell-specific prostaglandin synthases convert PGH2 into a series of prostaglandins, including PGI2, PGF2alpha, PGD2 and PGE2 (Fig. 1). Fig. 1 Legend - Pathway of prostaglandin production. Arachidonic acid is liberated from membranes by phospholipase A2. The cyclooxygenase enzymes (COX-1 and COX-2) produce prostaglandin H2 (PGH2) from arachidonic acid. PGH2 is acted upon by prostaglandin synthases to produce PGI2, PGD2, PGE2 and PGF2alpha. PGD2 is metabolized to 15-deoxy-12,14-PGJ2 (15-d-PGJ2). " provenance.
- _4 value "Cell-specific prostaglandin synthases convert PGH2 into a series of prostaglandins, including PGI2, PGF2alpha, PGD2 and PGE2 (Fig. 1). Fig. 1 Legend - Pathway of prostaglandin production. Arachidonic acid is liberated from membranes by phospholipase A2. The cyclooxygenase enzymes (COX-1 and COX-2) produce prostaglandin H2 (PGH2) from arachidonic acid. PGH2 is acted upon by prostaglandin synthases to produce PGI2, PGD2, PGE2 and PGF2alpha. PGD2 is metabolized to 15-deoxy-12,14-PGJ2 (15-d-PGJ2). " provenance.
- _4 value "Cell-specific prostaglandin synthases convert PGH2 into a series of prostaglandins, including PGI2, PGF2alpha, PGD2 and PGE2 (Fig. 1). Fig. 1 Legend - Pathway of prostaglandin production. Arachidonic acid is liberated from membranes by phospholipase A2. The cyclooxygenase enzymes (COX-1 and COX-2) produce prostaglandin H2 (PGH2) from arachidonic acid. PGH2 is acted upon by prostaglandin synthases to produce PGI2, PGD2, PGE2 and PGF2alpha. PGD2 is metabolized to 15-deoxy-12,14-PGJ2 (15-d-PGJ2). " provenance.
- _3 value "Substantially elevated levels of nuclear Sp1 was observed in keratinocytes stimulated with Ca2+." provenance.
- _3 value "Treatment of human keratinocytes with Ca2+ increases the PKC-delta tyrosine phosphorylation." provenance.
- _3 value "AP-1 sites contributed to Ca(2+)-mediated VEGF-Luc induction In addition, dominant-negative AP-1 diminished the expression of the NDRG-1/Cap43 gene following hypoxia." provenance.
- _3 value "We conclude that during hypoxia, an increase in intracellular Ca(2+) activates a HIF-1-independent signaling pathway that involves AP-1-dependent transcription." provenance.
- _2 value "SC4, the acidic polysaccharide with complicated structure, was a B-lymphocyte stimulator and protected PC12 cells at the concentration of 20 mg/L against H2O2-induced injury." provenance.
- _5 value "SC4, the acidic polysaccharide with complicated structure, was a B-lymphocyte stimulator and protected PC12 cells at the concentration of 20 mg/L against H2O2-induced injury." provenance.
- _4 value "Proinflammatory cytokines such as tumor necrosis factor (TNF)-alpha are involved in asthma and may interfere with epithelial integrity... After 48 h of TNF-alpha stimulation with or without dexamethasone expression of E-cadherin, beta-catenin and gamma-catenin were analyzed using Western blot analysis and immunofluorescence. This study showed a decrease in the expression of adhesion molecules in both epithelial cell cultures after stimulation. Dexamethasone and anti-TNF-alpha inhibited this effect." provenance.
- _5 value "GM-CSF signals through JAK2 and STAT5 and stimulates the expression of STAT5 target genes, such as pim-1 and CIS." provenance.
- _6 value "GM-CSF signals through JAK2 and STAT5 and stimulates the expression of STAT5 target genes, such as pim-1 and CIS." provenance.
- _5 value "GM-CSF signals through JAK2 and STAT5 and stimulates the expression of STAT5 target genes, such as pim-1 and CIS." provenance.
- _3 value "Like prostaglandins, the COX substrate, arachidonic acid, also induced mdr1b gene expression." provenance.
- _5 value "induction of DN-Foxa2 also reduces the expression of beta-cell K(ATP) channel subunits Sur1 and Kir6.2 by 70%." provenance.
- _6 value "Modified assertion" provenance.
- _5 value "inhibitors of protein kinase A and phospholipase C mediated signalling. Our results demonstrate that both pathways are involved in VIP induced per gene expression" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _6 value "ANGPTL3 bound to alpha(v)beta(3) and induced integrin alpha(v)beta(3)-dependent haptotactic endothelial cell adhesion and migration and stimulated signal transduction pathways characteristic for integrin activation, including phosphorylation of Akt, mitogen-activated protein kinase, and focal adhesion kinase" provenance.
- _8 value "ANGPTL3 bound to alpha(v)beta(3) and induced integrin alpha(v)beta(3)-dependent haptotactic endothelial cell adhesion and migration and stimulated signal transduction pathways characteristic for integrin activation, including phosphorylation of Akt, mitogen-activated protein kinase, and focal adhesion kinase" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "Modified assertion" provenance.
- _2 value "In rat lung and cultured lung vascular cells, hypoxia decreases ornithine decarboxylase (ODC) activity and increases polyamine import" provenance.
- _3 value "constitutive Akt signaling is believed to promote proliferation and increased cell survival and thereby contribute to cancer progression" provenance.
- _4 value "Both eNOS and iNOS expression seemed to increase during perindopril treatment." provenance.
- _4 value "In particular, the human protein is identical to P34H, except for one amino acid substitution. The purified recombinant proteins of the five species were about 100-kDa homotetramers with NADPH-linked reductase activity for alpha-dicarbonyl compounds, catalyzed the oxidoreduction between xylitol and l-xylulose, and were inhibited competitively by n-butyric acid" provenance.
- _5 value "both CBP and p300 are indispensable for the full activation of PPARgamma and adipocyte differentiation and that CBP and p300 do not mutually complement in the process." provenance.
- _5 value "In contrast, these increases in lung collagen and BAL HA content were significantly reduced in CC10-IL-13 mice with null CCR2 loci (Fig. 5)." provenance.
- _3 value "In the CC10-IL-13 mice, progressive lung pathology is noted. At 1 mo of age, these animals manifest peribronchial inflammation, mucus metaplasia, alveolar enlargement, and subepithelial fibrosis (10)." provenance.
- _4 value "Previous studies from our laboratory demonstrated that the levels of MMP-2, MMP-9, MMP-12, and cathepsins B, S, K, and L are increased in IL-13 transgene mice ... animals (13)." provenance.
- _3 value "TGF-1 is a potent stimulator of HA production and tissue fibrosis (18, 33?35)." provenance.
- _5 value "We show that stimulation of murine and human macrophages with the heat shock proteins gp96 and hsp70 results in induction of inducible NO synthase and the production of NO." provenance.
- _5 value "Hes1 promoter activity is repressed by N-CoR, and this effect is reversed by ectopic expression of p65-NF{kappa}B..." provenance.
- _4 value "Acute treatment with the PKC agonist TPA stimulated phosphorylation of both isoforms of GSK-3 in Swiss 3T3 (Fig. 6A) and other cell lines, including HEK293 (data not shown), providing further support for the involvement of PKC in the regulation of GSK-3." provenance.
- _6 value "In addition, HRG stimulation of breast cancer cells promoted phosphorylation of G3BP and increased the association of G3BP with GTPase-activating protein, both of which are essential for G3BP activity" provenance.
- _5 value "the PLAG1- and PLAGL2-induced transformation is accompanied by a drastic up-regulation of insulin-like growth factor-II, which we prove is a target of PLAG1 and PLAGL2" provenance.
- _7 value "addition of exogenous-recombinant HSP60 was sufficient to specifically activate alpha 3 beta 1 integrin" provenance.
- _9 value "mizoribine, an HSP60-binding drug, blocked activation of the alpha 3 beta 1 integrin induced by insulin-like growth factor 1 (IGF1) or exogenous recombinant HSP60 and inhibited the association of HSP60 with the integrin" provenance.
- _5 value "In lung fibroblasts, elastase is known to initiate shedding of heparan sulfate proteoglycans (17), extracellular molecules serving as docking sites for multiple growth factors, such as basic fibroblast growth factor (bFGF) and transforming growth factor (18, 19). This shedding, in turn, leads to reduction of bFGF binding to its high affinity receptors (17)." provenance.
- _5 value "Modified assertion" provenance.
- _5 value "Modified assertion" provenance.
- _4 value "The p53-related protein p73 has many functions similar to that of p53 including the ability to induce cell-cycle arrest and apoptosis" provenance.
- _3 value "NMDA leads to an increase in endogenous IL-1beta synthesis." provenance.
- _3 value "the concentrations of proinflammatory cytokines, such as interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma were highly increased during sepsis" provenance.
- _3 value "the concentrations of proinflammatory cytokines, such as interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma were highly increased during sepsis" provenance.
- _5 value "Modified assertion" provenance.
- _5 value "Modified assertion" provenance.
- _3 value "Resveratrol increases the expression of p53, tumor suppressor protein, prior to NAG-1 induction, indicating that NAG-1 expression by resveratrol is mediated by p53 expression." provenance.