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- _5 value "At early developmental stages,SGK is first expressed in the decidua and yolk sac and is highly expressed in heart tissue, blood vessels and lung buds, suggesting a potential role for this protein kinase in heart development and or blood vessel formation [53]. As reviewed elsewhere [61-63], the phosphoinositide dependent protein kinase-1 (PDK1) is activated directly down-stream of PI 3-kinase [22, 28]. Full stimulation of SGK enzymatic activity requires the PDK-1 dependent phosphorylation at amino acid residue threonine 256 within the activation loop of SGK, and phosphorylation at serine 422 in the carboxyterminal domain, presumably by a PDK-1-like enzyme [22, 28]." provenance.
- _5 wasQuotedFrom 12649597 provenance.