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- _2 value " In the presence of CPT, topo I forms a covalent intermediate with the 3'-phosphate end of the broken DNA strand (5) . This single-strand nick lesion is believed to convert into an irreversible double-strand break after it encounters the replication fork machinery in S phase. This unusual form of DNA damage induces a signaling cascade that is propagated by ATM-family kinases in human cells (6) , which phosphorylate numerous targets involved in transcription, DNA repair, cell cycle arrest, and apoptosis." provenance.
- _2 wasQuotedFrom 15026349 provenance.